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What is NMN?
NMN or nicotinamide mononucleotide is a naturally occurring compound that stimulates production of another compound, called NAD or nicotinamide adenine dinucleotide. As part of the aging process, our body produces less NAD as we get older.
Sadly, when NAD levels drop with age, inflammation or rusting of the body, shoots up. As studies have shown keeping inflammation low throughout our life is a key factor to living to 110 and beyond, anything we can do to keep inflammation low will help us to enjoy great health at old age. Thus, more NAD and less inflammation could be the way to reverse aging with NMN.
As keeping NAD levels high is important to slow aging and keep inflammation at a minimum, many longevity researchers, including Dr. Shin-ichiro Imai, MD, PhD from the Washington University School of Medicine, tried to see if they could reverse aging with NAD supplements. Sadly, his research, as well as research from other longevity studies, failed.
Because NAD supplements failed to reverse aging, Dr. Imai and his colleagues approached later this challenge from a different angle. Rather than to give NAD supplements, they gave mice NMN supplements and then let the mice naturally boost NAD by converting NMN to NAD.
That study was very successful. Newspapers around the world reported that Dr. Imai may have found the “fountain of youth.
Promising NMN Mouse Study
In the NMN mouse study, Dr. Imai and colleagues took adult lab mice and then randomized them to one of three treatment groups. The first group was treated with low-dose NMN dissolved into their drinking water. The second treatment group drank high-dose NMN in their water. Lastly, the third group had nothing added to their water.
Dr. Imai and his team them followed these mice very closely for one year. As lab mice typically live only two years, they followed these mice until old age.
These Washington University researchers found that NMN was absorbed within minutes to the blood stream of mice. Once inside the blood stream, NMN was converted to NAD thereby boosting NAD levels in these mice.
One theoretical concern was that boosting NAD levels could cause tumors to form in these mice. Fortunately, no tumors or any other complications were observed with NMN supplementation.
Interestingly, the observed NMN benefit was only seen in older mice. Dr. Imai theorized that this was because younger mice made enough NAD so their low levels of inflammation weren’t helped by NMN supplementation.
Benefits of NMN
Quite remarkably, the study showed that old mice could be made young, thin, and energetic again with NMN. Indeed, they convincingly showed that you could reverse aging with NMN. Below are the key findings of this study.
1. Lower body weight
In this study, mice fed low-dose NMN lost 4% of their body weight. Those fed high-dose NMN lost 9% of their body weight.
To translate these findings, a 9% weight loss in a 200 pound person would be the equivalent of losing 18 pounds. Even more remarkable was that even though the mice on NMN ate much more, they still lost weight!
2. Increased energy/better mitochondrial function
The mitochondria is the energy power plant of cells. In this study, mice given NMN were much more energetic and had better energy production from their mitochondria.
3. Less diabetes
Mice on NMN showed much better insulin sensitivity. Better insulin sensitivity means less diabetes. Even heavier mice on NMN showed better insulin sensitivity.
4. Lower cholesterol and triglycerides
Researchers found that NMN also dropped cholesterol and triglyceride levels. However, this drop was primarily seen in those mice on high-dose NMN.
5. Less activation of aging genes
As NMN and NAD both activate the SIRT1 longevity gene, these Washington University researchers observed marked activation of longevity genes and suppression of aging genes.
6. Improved eye sight
Researchers found that the retinas in mice functioned much better with NMN supplementation. Also, the older mice were even less likely to suffer from dry eyes.
7. Increased bone density and muscle
Mice treated with NMN also had stronger muscles and bones. Interestingly, the 513 genes that cause loss of muscle and bone density with aging were all suppressed with NMN in this study.
8. Better immune system function
Lastly, NMN treated mice showed better immune function. Better functioning of the immune system means less infections and and less cancer.
NMN Dietary Supplements
Produced by GENE Formulas
About the product
- Sublingual Delivery UNNECESSARY! NMN Capsules Proven to be BIOAVAILABLE – Newly Discovered NMN Transporter Slc12a8 shows NMN is directly and very rapidly absorbed in the small intestines creating NAD+ in the tissue within10-30 min.
- Certified 99% Pure NMN – Direct NAD+ Precursor Supplement for Healthy Aging & DNA-Repair.
- Boost Energy Metabolism – NAD+ helps breakdown food (sugars) into energy.
- SIRTUIN Activator – NAD+ is required for our longevity genes to work.
- Dr. Sinclair’s Recent trials show Old Mice treated with NMN restored youthful blood vessel capillary density.
Price: $ 55.87
About the product: NMN 250mg Serving 3Pack Nicotinamide Mononucleotide Direct NAD+ Supplement, Anti Aging DNA Repair & Healthy Metabolism (2X 125mg caps 60 ct per Bottle).
ⓘ If you select NMN 3Pack by clicking on the label or on the picture
you will be redirected to ebay .
About the product
Flush Free Niacin Formula – Support Energy Production, Metabolism, Niacinimide – Gluten Free – Vegetarian – Non GMO-GMP
ⓘ If you select Nicotinamide by clicking on the label or on the picture you will be redirected to EBAY.
NMN in Foods
As many studies evaluating supplements in humans often produce unintended side effects or toxicities, it is always best to get everything you need from natural food sources.
Fortunately, NMN is found naturally in many foods. Below are the six foods highest in NMN.
In addition to NMN, eating more of these six foods will help your overall health in so many other ways. However, we should point out that if we want to reverse aging with NMN, we will have to eat large amounts of each of these foods. Sadly, the NMN in a few stems of broccoli is hardly enough to even begin to boost NMN levels.
The message of this study is that we may be able reverse aging with NMN. Our best bet is to eat more broccoli, cabbage, cucumber, edamame, avocado, and tomato. But we could also take the anti-aging NMN dietary suppement, if need be in combination with another good anti-aging dietary supplement, for example Resveratrol .