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What Is Resveratrol?

This compound tends to be concentrated mostly in the skins and seeds of grapes and berries.

These parts of the grape are included in the fermentation of red wine, hence its particularly high concentration of resveratrol.

Resveratrol is a plant compound that acts like an antioxidant. The top food sources include red wine, grapes, some berries and peanuts.

Much of the research on resveratrol has been done in animals and test tubes using high amounts of the compound.

Of the limited research in humans, most has focused on supplemental forms of the compound, in concentrations higher than those you could get through food.

Health Benefits of Resveratrol Supplements

Resveratrol Supplements May Help Lower Blood Pressure

Because of its antioxidant properties, resveratrol could be a promising supplement for lowering blood pressure.

A 2015 review concluded that high doses may help reduce the pressure exerted on artery walls when the heart beats.

That type of pressure is called systolic blood pressure, and appears as the upper number in blood pressure readings.

Systolic blood pressure typically goes up with age, as arteries stiffen. When high, it’s a risk factor for heart disease.

Resveratrol may accomplish this blood-pressure-lowering effect by helping to produce more nitric oxide, which causes blood vessels to relax.

However, the authors of the study say more research is needed before specific recommendations can be made about the best dose of resveratrol to maximize blood pressure benefits.

Resveratrol Has a Positive Effect on Blood Fats

Several studies in animals have suggested that resveratrol supplements may change blood fats in a healthy way.

A 2016 study fed mice a high-protein, high-polyunsaturated fat diet and also gave them resveratrol supplements.

Researchers found the average total cholesterol levels and body weight of the mice decreased, and their levels of “good” HDL cholesterol increased.

Resveratrol seems to influence cholesterol levels by reducing the effect of an enzyme that controls cholesterol production.

As an antioxidant, it also may decrease the oxidation of “bad” LDL cholesterol. LDL oxidation contributes to plaque buildup in artery walls.

In one study, participants were given grape extract that had been boosted with extra resveratrol.

After six months of treatment, their LDL had gone down by 4.5% and their oxidized LDL had gone down by 20% compared to participants who took an unenriched grape extract or a placebo.

It Lengthens Lifespan in Certain Animals

The compound’s ability to extend lifespan in different organisms has become a major area of research.

There’s evidence that resveratrol activates certain genes that ward off the diseases of aging.

It works to achieve this in the same way as calorie restriction, which has shown promise in lengthening lifespans by changing how genes express themselves.

However, it’s not clear if the compound would have a similar effect in humans.

A review of studies exploring this connection found that resveratrol increased lifespan in 60% of the organisms studied, but the effect was strongest

in organisms that were less related to humans, such as worms and fish.

Resveratrol Supplements and Brian Health Combined with its antioxidant properties, resveratrol has also been shown to act as a potent natural anti-inflammatory. As a result, resveratrol has been shown to protect brain cells from oxidative and inflammatory driven damage.

With this in mind, resveratrol supplementation has been strongly recommended to reduce the risk of developing age related declines in cognitive function, while also being used to protect against neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

Resveratrol May Increase Insulin Sensitivity

Resveratrol has been shown to have several benefits for diabetes, at least in animal studies.

These benefits include increasing insulin sensitivity and preventing complications from diabetes.

One explanation for how resveratrol works is that it may stop a certain enzyme from turning glucose into sorbitol, a sugar alcohol.

When too much sorbitol builds up in people with diabetes, it can create cell-damaging oxidative stress.

Here are a few more benefits resveratrol may have for people with diabetes:

⦁ May protect against oxidative stress: Its antioxidant action may help protect against oxidative stress, which causes some of the complications of diabetes.

⦁ Helps decrease inflammation: Resveratrol is thought to lessen inflammation, a key contributor to chronic diseases, including diabetes.

⦁ Activates AMPK: This is a protein that helps the body metabolize glucose. Activated AMPK helps keep blood sugar levels low.

Resveratrol may even provide more benefits for people with diabetes than those who don’t have it. In one animal study, red wine and resveratrol were actually more effective antioxidants in rats with diabetes than in rats who didn’t have it.

Researchers say the compound could be used to treat diabetes and its complications in the future, but more research is needed.

Resveratrol May Ease Joint Pain

Arthritis is a common affliction that leads to joint pain and loss of mobility.

Plant-based supplements are being studied as a way to treat and prevent joint pain. When taken as a supplement, resveratrol may help protect cartilage from deteriorating.

Cartilage breakdown can cause joint pain and is one of the main symptoms of arthritis.

One study injected resveratrol into the knee joints of rabbits with arthritis and found that these rabbits suffered less damage to their cartilage.

Other research in test tubes and animals has suggested that the compound has potential to reduce inflammation and prevent damage to joints.

Resveratrol Supplements and Cancer

And finally, combined with the above, there is evidence to suggest that increasing your intake of resveratrol may even assist in the prevention of cancer.

Resveratrol has been shown to interact with cancerous cells at a physiological level, by directly inhibiting their growth, and altering their gene expression.

As such, resveratrol offers an excellent option to reduce our risk of developing cancer, and may even provide an excellent addition to traditioncancer treatments.

Risks and Concerns Regarding Resveratrol Supplements

No major risks have been revealed in studies that have used resveratrol supplements. Healthy people seem to tolerate them well. However, it should be noted that there aren’t enough conclusive recommendations about how much resveratrol a person should take in order to get health benefits.

And there are some cautions, especially regarding how resveratrol could interact with other medications.

Since high doses have been shown to stop blood from clotting in test tubes, it’s possible it could increase bleeding or bruising when taken with anti-clotting drugs, such as heparin or warfarin, or some pain relievers.

Resveratrol also blocks some enzymes that help clear certain compounds from the body. That means some medications could build up to unsafe levels.

These include certain blood pressure medications, anxiety meds and immunosuppressants.

If you currently use medications, then you may want to check with a doctor before trying resveratrol.

Lastly, it’s widely debated how much resveratrol the body can actually use from supplements and other sources.

However, researchers are studying ways of making resveratrol easier for the body to use.

While resveratrol supplements are likely safe for most people, they could interact with certain medications and there’s not yet clear guidance on how to use them effectively.

Some of the Best Resveratrol Supplements

aSquared Nutrition Resveratrol

by aSquared Brands

About the product: 100% Pure Resveratrol – 1000mg Per Serving Max Strength (180 Capsules) Antioxidant Supplement Extract, Natural Trans-Resveratrol

Pills for Heart Health & Weight Loss, Trans Resveratrol for Anti-Aging.

Price: $27.99

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NOW Foods Mega Potency Natural Resveratrol 200 mg, 120 Vegetarian Capsules

Warnings: This product may cause digestive upset in some sensitive individuals. If you experience any gastrointestinal discomfort after using this product, discontinue its use. Keep out of reach of children. Keep your health care practitioner informed while using this product. Do not consume freshness packet.


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Resveratrol 1450

by NutraSkye Labs

About the product

RESVERATROL1450-90day Supply, 1450mg per Serving of Potent Antioxidants & Trans-Resveratrol, Promotes Anti-Aging, Cardiovascular Support, Maximum Benefits.

PURELY Beneficial has a resveratrol supplement that uses Japanese knotweed as its primary resveratrol source. However, in addition to the resveratrol, there is a polyphenol complex from green tea extract, grape seeds, acai, and other strong antioxidant compounds. On top of that, there’s 200% of your recommended daily intake of vitamin C.

Price: $34.79

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Nutrivein Resveratrol 1450mg – 120 Capsules – Anti-Aging Antioxidant Supplement


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Resveratrol 1000mg 180 Capsules, Pure; Support Heart & Cardiovascular Health

Price: $19.87

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by NutraChamps Inc

About the product:   Resveratrol Supplement 1400mg - Extra Strength Formula for Maximum Anti Aging, Immune & Heart Health  60 Vegan Capsules with Trans-Resveratrol, Green Tea Leaf, Acai Berry & Grape Seed Extract.

Price: $27.33

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Optimized Resveratrol

Life Extension Optimized Resveratrol Defense Against Cellular Aging, 60 Capsules


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Resveratrol is one of the most bioactive compounds on the entire planet, where it can lower blood pressure, improve blood cholesterol levels, reduce our risk of developing cancer, and even improve brain health and cognitive function.

It is for these key reasons that resveratrol makes an excellent addition to anyone’s supplement regime.


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